Arp2/3 complex-driven spatial patterning of the B cell receptor (BCR) enhances immune synapse formation, BCR signaling, and cell activation
M. Bolger-Munro, K. Choi, J. Scurll, L. Abraham, R. Chappell, D. Sheen, M. Dang-Lawson, X. Wu, J. J. Priatel, D. Coombs, J. A. Hammer, M. R. Gold
The paper shows that Arp2/3 complex-driven spatial reorganization of BCR microclusters enhances immune synapse formation, BCR signaling, and B cell activation in response to membrane-bound antigens.
bioRxiv · Apr 30, 2019Immunology