MAPK and mTORC1 signaling converge on Cyclin D to enable cell-cycle re-entry in melanoma persister cells
Varuna Nangia, Humza M. Ashraf, Nasreen C. Marikar, Victor J. Passanisi, R. Christopher, Sabrina L. Spencer
The paper identifies Cyclin D1 accumulation as a critical bottleneck for cell-cycle re-entry in drug-treated melanoma cells, driven by MAPK and mTORC1 signaling integration.
Science Signaling · Sep 2, 2025Peer-reviewedSystems Biology