Author

Humza M. Ashraf

University of Colorado BoulderORCID 0000-0001-7042-312XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 2 Assay:imaging· 2 Approach:statistical model· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Sabrina L. SpenceriD· 3 shared Brianna Fernandez· 2 shared Victor J. PassanisiiD· 2 shared Nasreen C. Marikar· 1 shared R. Christopher· 1 shared Varuna NangiaiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 12 mutual co-author links

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3 shared papersSystems Biology

Sabrina L. SpencerORCID

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3 papers

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedDec 23, 2025

Single-cell RNA sequencing reveals distinct senotypes and a quiescence-senescence continuum at the transcriptome level following chemotherapy

Brianna Fernandez, Victor J. Passanisi, Humza M. Ashraf, Sabrina L. Spencer

The paper uses single-cell RNA sequencing and time-lapse imaging to distinguish quiescence and senescence after chemotherapy, revealing a continuum of cell-cycle withdrawal.

18 citationstop 1%

humanscRNA-seq

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Systems BiologyScience SignalingPeer-reviewedSep 2, 2025

MAPK and mTORC1 signaling converge on Cyclin D to enable cell-cycle re-entry in melanoma persister cells

Varuna Nangia, Humza M. Ashraf, Nasreen C. Marikar…·Sabrina L. Spencer

The paper identifies Cyclin D1 accumulation as a critical bottleneck for cell-cycle re-entry in drug-treated melanoma cells, driven by MAPK and mTORC1 signaling integration.

8 citations

humanimaging

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Systems BiologyNature CommunicationsPeer-reviewedJul 27, 2023

The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal

Humza M. Ashraf, Brianna Fernandez, Sabrina L. Spencer

The study shows that senescence biomarker intensities reflect the duration of cell-cycle withdrawal, suggesting quiescence and senescence are part of a continuum.

74 citationstop 1%

imagingexperimental assay

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