Sabrina L. Spencer

This study shows that KRASG12C inhibition induces chromosomal instability (CIN) in NSCLC cells, which synergizes with Aurora Kinase A inhibition to enhance therapeutic efficacy.

The paper uses single-cell RNA sequencing and time-lapse imaging to distinguish quiescence and senescence after chemotherapy, revealing a continuum of cell-cycle withdrawal.

The paper shows that p16 expression in ovarian cancers increases sensitivity to CDK2 inhibitors by inhibiting CDK4/6, suggesting p16 as a biomarker for CDK2 inhibitor response.

The paper identifies Cyclin D1 accumulation as a critical bottleneck for cell-cycle re-entry in drug-treated melanoma cells, driven by MAPK and mTORC1 signaling integration.

This study identifies CDK7-dependent mechanisms regulating RNAPII function at gene 5'- and 3'-ends through biochemical reconstitution and multi-omics analysis.

The paper identifies off-target activation of GCN2 by BRAF and EGFR inhibitors, showing it limits cancer cell proliferation.

This study investigates the acute effects of CAF-1 loss on chromatin assembly during S-phase, revealing multi-level responses including replication slowdown and histone modification changes.

This study examines ECM protein composition changes during murine forelimb development using mass spectrometry and BONCAT, revealing dynamic differences in matrisome composition across developmental stages and tissue types.

The study shows that senescence biomarker intensities reflect the duration of cell-cycle withdrawal, suggesting quiescence and senescence are part of a continuum.

The paper investigates how varying ERK activity levels influence proliferation in cells undergoing oncogene-induced senescence, finding intermediate ERK activity promotes maximal proliferation.

This study shows stress granules promote chemoresistance by inducing cellular quiescence through cell-cycle exit.

EllipTrack is a cell-tracking pipeline that improves accuracy in long-term 2D fluorescence time-lapse microscopy by combining global track-linking and local track-correction.

The paper introduces a CDK sensor to distinguish cycling cells from terminally differentiated cells in C. elegans and zebrafish, revealing commitment points and stochasticity in cell cycle control.