Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-induced Weight Gain in Male Mice
E. M. Morris, R. D. Noland, M. E. Ponte, M. L. Montonye, J. A. Christianson, J. A. Stanford, J. M. Miles, M. R. Hayes, J. P. Thyfault
This study shows that reduced liver-specific PGC1a in male mice increases diet-induced weight gain and energy imbalance, but not in females, and that vagal signaling affects this effect in wildtype but not in PGC1a-deficient mice.
bioRxiv · Dec 4, 2020Physiology