Cancer BiologybioRxiv
Activation of targetable inflammatory immune signaling is seen in Myelodysplastic Syndromes with SF3B1 mutations
G. Choudhary, A. Pellagatti, B. Agianian…·A. Verma
This study identifies a longer, oncogenic IRAK4 isoform caused by SF3B1 mutations in MDS/AML, which is targetable by IRAK4 inhibition.
DOI 10.7554/elife.78136