Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism.
B. Harris, D. K. Singh, B. Truong, M. Rhodes, R. Price, S. Shinton, M. Verma, B. Aylward, S. P. Fahl, S. R. Sprinkle, S. Aminov, M. Wang, Y. Zhang, J. Perrigoue, R. Kessel, , D. L. Wiest
This study shows that reduced RPL22 expression in hematopoietic stem cells promotes leukemia by altering metabolism and increasing lipid synthesis via Lin28b.
bioRxiv · May 31, 2023Cancer Biology