Author

R. E. McHugh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

A. J. A. Roe· 1 shared A. J. Roe· 1 shared A. Taladriz-Sender· 1 shared D. Mark· 1 shared F. Peschke· 1 shared G. A. Burley· 1 shared I. J. W. McKean· 1 shared J. M. Giard· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

A. J. A. Roe

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2 papers

Recent·Most cited

Aurodox, a polyketide from Streptomyces goldiniensis, inhibits transcription of the type III secretion system of multiple Gram-negative pathogens

D. Mark, N. O'Boyle, K. Wale, S. K. Tucker, R. E. McHugh, A. J. Roe

This study investigates aurodox's effect on T3SS in multiple Gram-negative pathogens, showing it inhibits some but not all T3SS systems, with selectivity observed across different strains.

bioRxiv · Apr 19, 2024 · PreprintMicrobiology

Biosynthesis of aurodox, a Type III secretion system inhibitor from Streptomyces goldiniensis

R. E. McHugh, J. T. Munnoch, R. E. Braes, I. J. W. McKean, J. M. Giard, A. Taladriz-Sender, F. Peschke, G. A. Burley, A. J. A. Roe, P. A. Hoskisson

This paper characterizes the aurodox biosynthetic gene cluster in Streptomyces goldiniensis and identifies key enzymatic steps responsible for its anti-virulence activity against EHEC.

bioRxiv · Feb 14, 2022Microbiology