P. A. Hoskisson

Fractal complexity of Escherichia coli nutrient transport channels is influenced by cell shape and growth environment

This study quantifies how E. coli biofilm channel complexity changes with cell shape and growth conditions using fractal analysis.

Time-lapse mesoscopy of Candida albicans and Staphylococcus aureus dual-species biofilms reveals a structural role for the hyphae of C. albicans in biofilm formation

The paper uses time-lapse mesoscopy to study dual-species biofilms of Candida albicans and Staphylococcus aureus, showing that C. albicans morphology affects biofilm structure and infection synergy.

Construction and Characterisation of a Structured, Tuneable, and Transparent 3D Culture Platform for Soil Bacteria

The paper develops a 3D culture platform for soil bacteria that is tunable, transparent, and compatible with imaging, demonstrating its use with Bacillus subtilis and Streptomyces coelicolor.

Biosynthesis of aurodox, a Type III secretion system inhibitor from Streptomyces goldiniensis

This paper characterizes the aurodox biosynthetic gene cluster in Streptomyces goldiniensis and identifies key enzymatic steps responsible for its anti-virulence activity against EHEC.

Intra-colony channel morphology in Escherichia coli biofilms is governed by nutrient availability and substrate stiffness

This study shows that nutrient availability and substrate stiffness influence intra-colony channel morphology in E. coli biofilms, with glucose-limited biofilms having wider central channels.

A mechanistic switch from selective transporter to an ion channel impairs the filamentation signalling capability of ammonium transceptors in yeast

The paper shows that variations in the Twin-His motif of Amt-Mep transporters switch their function from selective transport to non-specific ion channel activity, impairing filamentation signaling in yeast.

Frog nest foams exhibit pharmaceutical foam-like properties

This study shows that frog nest foams have stable, biocompatible properties and can encapsulate compounds like antibiotics, suggesting potential for pharmaceutical applications.

ActDES- a Curated Actinobacterial Database for Evolutionary Studies

The paper introduces ActDES, a curated database of 612 high-quality actinobacterial genomes, to facilitate evolutionary and metabolic studies.

Functional channels in mature E. coli colonies

The paper studies E. coli biofilms using Mesolens to identify functional channels that transport particles and aid nutrient absorption, suggesting new strategies for drug delivery.

Differential transcription of expanded gene families in central carbon metabolism of Streptomyces coelicolor A3(2)

The paper examines differential transcription of expanded gene families in Streptomyces coelicolor under different carbon sources, finding that two-thirds of these genes show transcriptional differences.

A two-lane mechanism for selective biological ammonium transport

The paper reveals a two-lane mechanism for selective ammonium transport in Amt/Mep/Rh transporters using electrophysiology, yeast complementation, and molecular dynamics simulations.

Three-dimensional observations of an aperiodic oscillatory gliding motility behaviour in Myxococcus xanthus using confocal interference reflection microscopy

This paper uses confocal interference reflection microscopy to observe 3D aperiodic oscillatory gliding motility in Myxococcus xanthus, revealing previously unseen height changes during movement.

Parasitic worm-derived ES-62 promotes health- and life-span in high calorie diet-fed mice

ES-62, a parasitic worm-derived immunomodulator, improves healthspan and extends lifespan in male mice fed a high-calorie diet.

Reconciling DNA replication and transcription in a hyphal organism: Spatial dynamics of transcription complexes in live Streptomyces coelicolor A3(2)

The paper observes spatial dynamics of transcription and DNA replication in Streptomyces hyphae, finding they are spatially separated to allow simultaneous use of DNA for both processes.

The parasitic worm product ES-62 normalises the gut microbiota/bone marrow axis in inflammatory arthritis

This study shows that the parasitic worm product ES-62 reduces joint inflammation in arthritis by normalising gut microbiota and preserving intestinal barrier integrity without requiring live helminth infection.

Merging in-solution X-ray and neutron scattering data allows fine structural analysis of membrane-protein detergent complexes

The paper combines SAXS and SANS data to analyze unlabeled membrane-protein detergent complexes, providing more detailed structural information than either method alone.

Sporulation-specific cell division defects in ylmE mutants of Streptomyces coelicolor are rescued by additional deletion of ylmD

This study shows that deletion of ylmE in Streptomyces coelicolor causes severe sporulation defects, which are rescued by also deleting ylmD.

The lipid environment determines the activity of the E. coli ammonium transporter, AmtB

This study shows that phosphatidylglycerol binding to AmtB is essential for its activity and stabilizes its structure, revealing new binding sites and functional roles.