Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized mice
M. M. Hernandez, A. Fahrny, A. Jayaprakash, G. Gers-Huber, M. Dillon-White, A. Audige, L. C. F. Mulder, R. Sachidanandam, R. F. Speck, V. Simon
This study shows that HIV variants with suboptimal anti-APOBEC3G activity are attenuated without treatment but gain a fitness advantage under antiretroviral therapy in humanized mice.
bioRxiv · Sep 11, 2019Microbiology