Author

R. Sachidanandam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

A. D. Jayaprakash· 2 shared A. Jayaprakash· 2 shared S. Hekmaty· 2 shared V. Simon· 2 shared A. Audige· 1 shared A. Bukreyev· 1 shared A. C. Iuga· 1 shared A. Fahrny· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

A. D. Jayaprakash

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4 papers

Recent·Most cited

The T cell receptor repertoire reflects the dynamics of the immune response to vaccination

K. Mohammed, A. Meadows, S. Hatem, S. Hekmaty, V. Simon, A. D. Jayaprakash, R. Sachidanandam

This study uses TCR repertoire sequencing to analyze immune responses to vaccines, finding broader T cell responses to COVID-19 than Influenza and TCR as a fingerprint for individual identification.

bioRxiv · Dec 9, 2021 · PreprintImmunology

Marburg and Ebola virus infections elicit a complex, muted inflammatory state in bats

A. D. Jayaprakash, A. J. Ronk, A. N. Prasad, M. F. Covington, K. R. Stein, T. M. Schwarz, S. Hekmaty, K. A. Fenton, T. W. Geisbert, C. F. Basler, A. Bukreyev, R. Sachidanandam

This study investigates how Marburg and Ebola viruses elicit a complex, muted inflammatory response in bats, revealing mechanisms that may explain their non-pathogenicity in these animals.

bioRxiv · Apr 13, 2020Microbiology

Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized mice

M. M. Hernandez, A. Fahrny, A. Jayaprakash, G. Gers-Huber, M. Dillon-White, A. Audige, L. C. F. Mulder, R. Sachidanandam, R. F. Speck, V. Simon

This study shows that HIV variants with suboptimal anti-APOBEC3G activity are attenuated without treatment but gain a fitness advantage under antiretroviral therapy in humanized mice.

bioRxiv · Sep 11, 2019Microbiology

Diet Modifies Colonic Microbiota and CD4+ T Cell Repertoire to Trigger Flares in a Novel Model of Colitis Induced by IL-23

L. Chen, Z. He, A. C. Iuga, S. M. Filho, J. J. Faith, J. C. Clemente, M. Deshpande, A. Jayaprakash, J.-F. Colombel, J. J. Lafaille, R. Sachidanandam, G. C. Furtado, S. A. Lira

This study shows that diet modifies the microbiota and CD4+ T cell repertoire in a mouse model of IL-23-induced colitis, leading to disease flares.

bioRxiv · Feb 19, 2018Immunology