LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis
X. Sun, R. FrancisThorne, X. D. Zhang, M. He, S.-S. Feng, X. Lu, M. Wu
This study identifies GUARDIN as a key regulator of cellular senescence through a LRP130-PGC1α-FOXO4-p21 signaling axis and shows its role in enhancing rapamycin's anti-senolytic effects.
bioRxiv · Jul 10, 2019Cell Biology