Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.
R. E. Joseph, T. E. Wales, S. Jayne, R. G. Britton, D. B. Fulton, J. R. Engen, M. J. S. Dyer, A. Andreotti
This study examines how different BTK inhibitors affect BTK conformation and explains resistance mutation patterns in CLL patients.
bioRxiv · Dec 18, 2023Biochemistry