Author

T. E. Wales

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

J. R. Engen· 5 shared D. Peterle· 2 shared A. Andreotti· 1 shared A. H. Andreotti· 1 shared A. Pajak· 1 shared A. Roeselova· 1 shared D. B. Fulton· 1 shared D. Balchin· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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5 shared papersBiochemistry

J. R. Engen

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Author profile →

5 papers

Recent·Most cited

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.

R. E. Joseph, T. E. Wales, S. Jayne, R. G. Britton, D. B. Fulton, J. R. Engen, M. J. S. Dyer, A. Andreotti

This study examines how different BTK inhibitors affect BTK conformation and explains resistance mutation patterns in CLL patients.

bioRxiv · Dec 18, 2023Biochemistry

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

D. Y.-w. Lin, L. E. Kueffer, P. Juneja, T. E. Wales, J. R. Engen, A. H. Andreotti

This study presents the first structural analysis of full-length BTK, revealing conformational heterogeneity in the PHTH-PRR region and providing insights into BTK activation mechanisms.

bioRxiv · Jun 2, 2023Biophysics

Increase the flow rate and improve hydrogen deuterium exchange mass spectrometry

D. Peterle, D. DePice, T. E. Wales, J. R. Engen

This paper improves hydrogen deuterium exchange mass spectrometry by increasing flow rates under quench conditions, enhancing separation efficiency and deuterium recovery.

Journal of Chromatography A · Jan 1, 2023Peer-reviewedBiophysics

Resolving chaperone-assisted protein folding on the ribosome at the peptide level

T. E. Wales, A. Pajak, A. Roeselova, S. Shivakumaraswamy, S. Howell, F.-U. Hartl, J. R. Engen, D. Balchin

This study uses HDX-MS to map the cotranslational folding pathway of E. coli dihydrofolate reductase, revealing structured intermediates and chaperone interactions on the ribosome.

bioRxiv · Sep 23, 2022Biochemistry

Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase

Z. Ji, H. Li, D. Peterle, J. A. Paulo, S. B. Ficarro, T. E. Wales, J. Marto, S. Gygi, J. R. Engen, T. A. Rapoport

This study elucidates how the Cdc48 ATPase complex unfolds and translocates polyubiquitinated protein substrates through cooperative binding with Ufd1/Npl4.

bioRxiv · Oct 21, 2021Biochemistry