Optogenetic Instruction of Cell Fate by Temporal Patterning of Mechanobiological Signals
R. G. Sampayo, M. Sakamoto, S. Kumar, D. V. Schaffer
This study shows that ECM stiffness regulates neural stem cell fate by modulating Rho GTPase activation frequency, with high-frequency activation promoting astrocytic differentiation and low-frequency activation driving neurogenesis.
bioRxiv · Sep 14, 2022 · PreprintCancer Biology