M. Sakamoto

Genome-wide CRISPR screen identifies AC9 as a key regulator of ER calcium homeostasis involved in neuronal differentiation.

The paper identifies AC9 as a key regulator of ER calcium homeostasis during neuronal differentiation using CRISPR screening and functional analysis.

Expression of transcription factors KLF2 and KLF4 is induced by the mammalian Golgi stress response

The paper identifies KLF2 and KLF4 as transcription factors induced by PG-type Golgi stress and involved in regulating proteoglycan pathways.

A highly contiguous genome assembly of red perilla (Perilla frutescens) domesticated in Japan

This paper presents a high-quality genome assembly of red perilla, identifying potential targets for genome editing to enhance metabolite production.

Optogenetic Instruction of Cell Fate by Temporal Patterning of Mechanobiological Signals

This study shows that ECM stiffness regulates neural stem cell fate by modulating Rho GTPase activation frequency, with high-frequency activation promoting astrocytic differentiation and low-frequency activation driving neurogenesis.

Targeting c-Jun is a potential therapy of luminal breast cancer bone metastasis

This study identifies c-Jun as a novel marker for luminal breast cancer bone metastasis and shows its inhibition reduces metastatic potential.

Fucosyltransferase 8 (FUT8) and core fucose expression in oxidative stress response

The paper introduces GlycoMaple, a tool predicting glycan structures from RNA-seq data, and shows FUT8 and core fucose expression increase during the antioxidant response.

MarpolBase Expression: A Web-based, Comprehensive Platform for Visualization and Analysis of Transcriptomes in the Liverwort Marchantia polymorpha

The paper introduces MBEX, a web-based platform for analyzing and visualizing transcriptomes in Marchantia polymorpha, demonstrating its utility through oil body biogenesis analysis.

Collection of 2429 constrained headshots of 277 volunteers for deep learning

The paper collects 2429 constrained headshots of 277 volunteers for deep learning, demonstrating its utility for gender recognition with convolutional neural networks.

HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

This study shows HOXB7 promotes transformation and lung metastasis in NMuMG cells via STAT3 activation.

Assessing bite force estimates in extinct mammals and archosaurs using phylogenetic predictions

The paper evaluates bite force estimates for extinct mammals and archosaurs using a Bayesian phylogenetic model, finding high accuracy comparable to extant data.

MGSE regulates crosstalk from the mucin pathway to the TFE3 pathway of the Golgi stress response

The paper identifies a novel mucin pathway that enhances glycosylation enzyme expression during mucin-type Golgi stress and shows it activates the TFE3 pathway through a specific enhancer element.

Extreme and rapid bursts of functional adaptations shape bite force in amniotes

The paper identifies bursts of exceptional adaptation in bite force across amniotes using a phylogenetic statistical approach, showing rate increases in specific groups but not generally.