Author

R. Georgescu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 4 Assay:cryo-EM· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

H. Li· 3 shared M. E. O'Donnell· 3 shared Z. Yuan· 3 shared D. Zhang· 2 shared L. Bai· 2 shared G. Zhao· 1 shared L. D. Langston· 1 shared M. O'Donnell· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

H. Li

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Molecular choreography of primer synthesis by the eukaryotic Pol α-primase

Z. Yuan, R. Georgescu, H. Li, M. E. O'Donnell

This study uses cryo-EM to analyze the structural dynamics of yeast Pol α-primase during primer synthesis, revealing how RNA primers are transferred to DNA polymerase and how primer length is regulated.

bioRxiv · May 3, 2023 · PreprintBiochemistry

Supporting evidence for DNA shearing as a mechanism for origin unwinding in eukaryotes

L. D. Langston, R. Georgescu, M. E. O'Donnell

The paper provides evidence that CMG complexes unwind DNA by shearing it apart while binding only one strand, using an origin mimic DNA with specific structural features.

bioRxiv · Aug 27, 2019 · PreprintBiochemistry

Ctf4 organizes sister replisomes and Pol alpha into a replication factory

Z. Yuan, R. Georgescu, R. d. L. Almeida Santos, D. Zhang, L. Bai, N. Y. Yao, G. Zhao, M. E. O'Donnell, H. Li

The paper shows Ctf4 organizes sister replisomes and Pol alpha into a replication factory by dimerizing CMG helicase and binding one Pol-primase.

bioRxiv · Aug 23, 2019Biochemistry

DNA unwinding mechanism of a eukaryotic replicative CMG helicase

Z. Yuan, R. Georgescu, L. Bai, D. Zhang, H. Li, M. O'Donnell

The paper reports the cryo-EM structure of the eukaryotic CMG helicase on forked DNA, revealing a 'dam-and-diversion tunnel' mechanism for DNA unwinding.

bioRxiv · Aug 15, 2019Biochemistry