Author

L. D. Langston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:DNA methylation· 1

Frequent Co-Authors

M. E. O'Donnell· 2 shared D. Zhang· 1 shared G. D. Schauer· 1 shared N. Y. Yao· 1 shared O. Yurieva· 1 shared R. E. Georgescu· 1 shared R. Georgescu· 1 shared R. Mayle· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

M. E. O'Donnell

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2 papers

Recent·Most cited

Supporting evidence for DNA shearing as a mechanism for origin unwinding in eukaryotes

L. D. Langston, R. Georgescu, M. E. O'Donnell

The paper provides evidence that CMG complexes unwind DNA by shearing it apart while binding only one strand, using an origin mimic DNA with specific structural features.

bioRxiv · Aug 27, 2019 · PreprintBiochemistry

Mcm10 functions to isomerize CMG-DNA for replisome bypass of DNA blocks

L. D. Langston, R. Mayle, G. D. Schauer, O. Yurieva, D. Zhang, N. Y. Yao, R. E. Georgescu, M. E. O'Donnell

This study shows Mcm10 enables CMG helicase to bypass DNA blocks on the non-tracking strand by isomerizing the CMG-DNA complex.

bioRxiv · Jun 6, 2017Biochemistry