Author

R. Gniadecki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:whole-exome sequencing· 5 Approach:statistical model· 4 Research Focus:clustering· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

A. Iyer· 5 shared D. Hennessey· 4 shared J. Patterson· 4 shared S. O'Keefe· 4 shared W. Wang· 3 shared G. K.-S. Wong· 2 shared G. Ka-Shu Wong· 2 shared A. Sivanand· 1 shared

Activity by Year

2018-2020 · peak 3/yr

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10 top collaborators · 32 mutual co-author links

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5 shared papersCancer Biology

A. Iyer

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5 papers

Recent·Most cited

The neoantigen landscape of mycosis fungoides

A. Sivanand, D. Hennessey, A. Iyer, S. O'Keefe, P. Surmanowicz, G. Vaid, R. Gniadecki

This study characterizes the neoantigen landscape in mycosis fungoides, finding high mutational load and neoantigen diversity, but also significant subclonality and patient-specific heterogeneity.

bioRxiv · Jan 22, 2020Cancer Biology

Independent evolution of cutaneous lymphoma subclones in different microenvironments of the skin

A. Iyer, D. Hennessey, S. O'Keefe, J. Patterson, W. Wang, G. K.-S. Wong, R. Gniadecki

This study shows that cutaneous lymphoma subclones evolve independently in different skin microenvironments, leading to ecological heterogeneity and intratumoral heterogeneity.

bioRxiv · Nov 4, 2019Cancer Biology

Branched evolution and genomic intratumor heterogeneity in the pathogenesis of cutaneous T-cell lymphoma

A. Iyer, D. Hennessey, S. O'Keefe, J. Patterson, W. Wang, G. K.-S. Wong, R. Gniadecki

This study identifies branched evolutionary patterns and intratumoral heterogeneity in mycosis fungoides, revealing complex clonal substructures and their implications for treatment resistance.

bioRxiv · Oct 15, 2019Cancer Biology

Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphoma

A. Iyer, D. Hennessey, S. O'Keefe, J. Patterson, W. Wang, G. Ka-Shu Wong, R. Gniadecki

This study identifies multiple neoplastic T-cell clones in MF lesions and peripheral blood, suggesting they continuously replenish lesions and contribute to tumor heterogeneity.

bioRxiv · Jul 16, 2019Cancer Biology

Clonotypic Heterogeneity In Cutaneous T-Cell Lymphoma Revealed By Comprehensive Whole Exome/Transcriptome Sequencing

A. Iyer, J. Patterson, T. Salopek, G. Ka-Shu Wong, R. Gniadecki

This study uses whole exome and transcriptome sequencing to analyze TCR clonality in mycosis fungoides, revealing multiple clonotypes in half of the samples, suggesting malignant transformation occurs at an early progenitor stage.

bioRxiv · Aug 31, 2018Cancer Biology