A. Iyer

Adaptive algorithms for shaping behavior

This paper develops a machine learning framework for shaping animal behavior using adaptive algorithms that alternate between simpler and harder tasks to optimize learning.

Simulated digestion, uptake and colonic fermentation of Gorse (Ulex europeaus) suggests safe use as a source of protein concentrates and potential bioactives.

The paper simulates digestion and fermentation of Gorse fractions to assess their safety and potential health benefits through microbial metabolite production.

Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum functions

This study shows that loss of Grp170 causes ER dysfunction, including BiP misregulation and UPR activation, leading to cell death in mouse embryonic fibroblasts.

Gorse (Ulex europeaus) wastes with 5,6-dimethyl benzimidazole supplementation can support growth of vitamin B12 producing commensal gut microbes

This study shows that Gorse waste can enhance B12 production by gut microbes, but yields are low, and three strains produce B12 for the first time.

The cut site specificity of the influenza A virus endoribonuclease PA-X allows it to discriminate between host and viral mRNAs

The paper identifies GCUG tetramers in hairpin loops as PA-X cleavage sites, showing PA-X discriminates host from viral mRNAs by targeting GCUG-rich regions prevalent in host transcripts.

A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression

The paper develops a computational model to study cell migration traits in tumor progression and finds that Giantin depletion increases intravasation, validated by lower Giantin levels in circulating tumor cells.

The endoplasmic reticulum membrane protein complex localizes to the mitochondrial - endoplasmic reticulum interface and its subunits modulate phospholipid biosynthesis in Trypanosoma brucei

This study identifies the TbEMC complex in Trypanosoma brucei, showing it localizes to the mitochondrial-ER interface and modulates phospholipid biosynthesis.

Oxygen-independent chemogenetic protein tags for live-cell fluorescence microscopy

This paper introduces oxygen-independent chemogenetic protein tags that enhance fluorescence and enable prolonged live-cell imaging under oxygen-free conditions.

The neoantigen landscape of mycosis fungoides

This study characterizes the neoantigen landscape in mycosis fungoides, finding high mutational load and neoantigen diversity, but also significant subclonality and patient-specific heterogeneity.

Optimal Mass Transport for Robust Texture Analysis

This paper introduces a texture analysis method using optimal mass transport to improve robustness in CT slice classification for head and neck cancer, outperforming random forest on scalar features.

Independent evolution of cutaneous lymphoma subclones in different microenvironments of the skin

This study shows that cutaneous lymphoma subclones evolve independently in different skin microenvironments, leading to ecological heterogeneity and intratumoral heterogeneity.

Branched evolution and genomic intratumor heterogeneity in the pathogenesis of cutaneous T-cell lymphoma

This study identifies branched evolutionary patterns and intratumoral heterogeneity in mycosis fungoides, revealing complex clonal substructures and their implications for treatment resistance.

Reproducibility test of radiomics using network analysis and Wasserstein K-means algorithm

This paper develops a network-based method to identify reproducible radiomic features across different imaging settings and validates it using phantom and external datasets.

Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphoma

This study identifies multiple neoplastic T-cell clones in MF lesions and peripheral blood, suggesting they continuously replenish lesions and contribute to tumor heterogeneity.

Precursor miRNAs are trafficked along axons associated with vesicles and locally processed to regulate growth cone steering

The paper shows that precursor miRNAs are transported along axons, processed into mature miRNAs, and regulate growth cone steering by inhibiting TUBB3 translation.

Clonotypic Heterogeneity In Cutaneous T-Cell Lymphoma Revealed By Comprehensive Whole Exome/Transcriptome Sequencing

This study uses whole exome and transcriptome sequencing to analyze TCR clonality in mycosis fungoides, revealing multiple clonotypes in half of the samples, suggesting malignant transformation occurs at an early progenitor stage.