Targeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence
J. Scott, M. Sueiro-Olivares, B. P. Thornton, R. A. Owens, H. Muhamadali, R. Fortune-Grant, D. Thomson, R. Thomas, K. Hollywood, S. Doyle, R. Goodacre, L. Tabernero, E. Bignell, J. Amich
This paper identifies methionine synthase as a promising antifungal target by showing its essentiality in Aspergillus fumigatus and validates its druggability using a genetic model of established infections.
bioRxiv · Jun 4, 2020Microbiology