Age of diabetes onset in the mutant proinsulin syndrome correlates with mutational impairment of protein foldability and stability
B. Dhayalan, Y.-S. Chen, Y. Yang, M. Jarosinski, D. Chatterjee, R. Grabowski, S. Poordian, N. F. B. Phillips, P. Arvan, F. Ismail-Beigi, M. A. Weiss
The paper investigates how mutations at position B18 in proinsulin affect protein foldability and stability, correlating these effects with the age of diabetes onset in mutant proinsulin syndrome.
bioRxiv · Sep 24, 2021 · PreprintBiochemistry