Author

M. A. Weiss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:human· 4 Research Focus:protein folding & dynamics· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

B. Dhayalan· 6 shared P. Arvan· 3 shared Y.-S. Chen· 3 shared F. Ismail-Beigi· 2 shared L. Haataja· 2 shared M. Liu· 2 shared N. Metanis· 2 shared O. Weil-Ktorza· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersBiochemistry

B. Dhayalan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Se-Glargine I. Chemical Synthesis of a Basal Insulin Analog Stabilized by an Internal Diselenide Bridge

O. Weil-Ktorza, B. Dhayalan, M. A. Weiss, N. Metanis

This paper describes the chemical synthesis of a basal insulin analog with an internal diselenide bridge, demonstrating improved stability and potential therapeutic applications.

ChemBioChem · Feb 2, 2024Peer-reviewedBiochemistry

Se-Glargine II. Native Function of a Basal Insulin Analog Stabilized by an Internal Diselenide Bridge

Y.-S. Chen, B. Dhayalan, Y. Yang, O. Weil-Ktorza, N. Metanis, M. A. Weiss

This paper describes an insulin analog with an internal diselenide bridge that maintains native function and stability, potentially improving insulin shelf life and accessibility.

bioRxiv · Jun 24, 2023 · PreprintBiochemistry

Stabilization of a Protein by a Single Halogen-Based Aromatic Amplifier

K. E. Hage, N. B. Phillips, Y.-S. Chen, B. Dhayalan, J. Whittaker, K. Carr, L. Whittaker, M. H. Phillips, F. Ismail-Beigi, M. Meuwly, M. A. Weiss

This study demonstrates that halogenation of an aromatic ring in insulin stabilizes the protein and enhances its resistance to fibrillation and biological activity.

bioRxiv · Jul 25, 2022Biochemistry

Age of diabetes onset in the mutant proinsulin syndrome correlates with mutational impairment of protein foldability and stability

B. Dhayalan, Y.-S. Chen, Y. Yang, M. Jarosinski, D. Chatterjee, R. Grabowski, S. Poordian, N. F. B. Phillips, P. Arvan, F. Ismail-Beigi, M. A. Weiss

The paper investigates how mutations at position B18 in proinsulin affect protein foldability and stability, correlating these effects with the age of diabetes onset in mutant proinsulin syndrome.

bioRxiv · Sep 24, 2021 · PreprintBiochemistry

Distinct states of proinsulin misfolding in MIDY

L. Haataja, A. Arunagiri, A. Hassan, K. Regan, B. Tsai, B. Dhayalan, M. A. Weiss, M. Liu, P. Arvan

The paper investigates proinsulin misfolding in MIDY mutants, showing that disrupting the Cys(A6)-Cys(A11) bond can restore proper folding and ER export in some mutants.

bioRxiv · May 10, 2021Biochemistry

Role of Proinsulin Self-Association in Mutant INS gene-induced Diabetes of Youth

M. Liu, P. Arvan, J. Sun, Y. Xiong, X. Li, L. Haataja, W. Chen, S. A. Mir, R. Madley, D. Larkin, A. Anjum, B. Dhayalan, N. K. Rege, N. D. Wickramasinghe, M. A. Weiss, , D. A. Ostrov

This study identifies proinsulin self-association as a mechanism driving dominant-negative effects of misfolded proinsulin in MIDY, offering a therapeutic target for enhancing insulin production.

bioRxiv · Oct 1, 2019Cell Biology