Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells.
R. Gualdani, F. Seghers, X. Yerna, O. Schakman, N. Tajeddine, Y. Achouri, F. Tissir, O. Devuyst, P. Gailly
The paper shows that TRPV4 channel activation by mechanical stretching in proximal tubule cells increases Ca2+ influx, promoting albumin reabsorption and reducing proteinuria.
bioRxiv · Feb 1, 2019Physiology