Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis via SYK activation
T. van der Wel, R. Hilhorst, H. den Dulk, T. van den Hooven, N. M. Prins, J. A. P. M. Wijnakker, B. I. Florea, E. B. Lenselink, G. J. P. van Westen, R. Ruijtenbeek, H. S. Overkleeft, A. Kaptein, T. Barf, M. van der Stelt
The paper uses a chemical genetics strategy to study FES kinase target engagement in human cells, revealing its role in neutrophil phagocytosis via SYK activation.
bioRxiv · Nov 13, 2019Physiology