R. Hillier

ZFHX3 plays a role in pain and cautious-like behaviours in mice

This study shows that ZFHX3 deficiency in mice leads to altered pain responses and reduced cautious-like behavior in both sexes, with female mice showing specific hypoalgesia to mechanical stimuli and hyperalgesia to heat.

A missense mutation in zinc finger homeobox-3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in mice.

This study shows that a ZFHX3 mutation in mice reduces body weight, alters metabolism, and changes hypothalamic gene expression related to growth and energy balance.