Patrick M. Nolan

This study identifies ZFHX3's role in regulating circadian gene expression in the SCN by mapping its genomic binding sites and analyzing transcriptomic changes in ZFHX3 mutants.

This study shows that a mutation in synaptobrevin 2 in mice leads to abnormal cortical activity patterns across sleep and wake states, resembling deep anaesthesia.

This study shows that ZFHX3 deficiency in mice leads to altered pain responses and reduced cautious-like behavior in both sexes, with female mice showing specific hypoalgesia to mechanical stimuli and hyperalgesia to heat.

The paper identifies SCN enhancers with 24-hour rhythmic H3K27ac modulation and links them to gene expression cycles through RNA-Seq and eRNA analysis.

This study uses home-cage video tracking to analyze voluntary behaviors in mice, revealing complex phenotypes and sexual dimorphism in a Huntington's disease model.

The paper phenotypes Dp1Tyb mice, a Down syndrome model, and identifies multiple DS-like traits including cognitive and physical abnormalities.

This study identifies a Vamp2 mutation in mice that causes sleep-wake transition deficits by reducing synaptic release probability.

This study shows that loss of Frrs1l in mice causes reduced synaptic AMPA receptor levels, leading to motor, cognitive, and electrographical abnormalities.