Developing Small Molecules that Inhibit K-Ras/GTP Binding Based on New Affinity Measurements
L. Carta, R. Hutcheson, S. A. Davis, M. J. Rudolph, C. H. Reynolds, M. Quick, T. M. Williams, M. Schmertzler, Y. R. Hadari
The paper reports new affinity measurements of K-Ras and its mutants for GTP, showing a 10,000-fold lower affinity than previously thought, and identifies over 400 small molecules that inhibit GTP binding to K-Ras.
bioRxiv · Jul 27, 2020 · PreprintCancer Biology