M. J. Rudolph

Single-domain antibodies reveal unique borreliacidal epitopes on the Lyme disease vaccine antigen, Outer surface protein A (OspA)

The paper identifies unique borreliacidal epitopes on OspA using VHHs and evaluates their reactivity across OspA serotypes.

Structural Elucidation of a Protective B cell Epitope on Outer Surface Protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

This paper determines the crystal structure of a protective B cell epitope on OspC, revealing its quaternary nature and informing vaccine design for Lyme disease.

The Flexible Linker of Decorin Binding Protein A from Borrelia burgdorferi is a Target of Antibodies in Lyme disease

The paper identifies a specific DbpA epitope targeted by antibodies in Lyme disease patients, suggesting it may block B. burgdorferi colonization.

Developing Small Molecules that Inhibit K-Ras/GTP Binding Based on New Affinity Measurements

The paper reports new affinity measurements of K-Ras and its mutants for GTP, showing a 10,000-fold lower affinity than previously thought, and identifies over 400 small molecules that inhibit GTP binding to K-Ras.

Intracellular Neutralization of Ricin Toxin by Single Domain Antibodies Targeting the Active Site Pocket

The paper identifies three potent single-domain antibodies that neutralize ricin toxin by targeting its active site, with structural insights into their mechanism of action.