T Cell Predominant Response to AAV-Spike Protects hACE2 Mice from SARS-CoV-2 Pneumonia
C. D. Greer, C. M. Kasden, L. Morales, K. A. Lundgreen, P. D. Hicks, L. J. Carpenter, C. Salas-Quinchucua, E. D. Tichy, A. M. Maguire, J. G. Hoffman, R. J. Bailey, S. Zhou, A. Luo, S. J. Chomistek, B. W. Kozyak, , H. H. Stedman
This study shows that AAV6 and AAV9 vaccines induce cellular immunity protecting mice from SARS-CoV-2 pneumonia without relying on neutralizing antibodies.
bioRxiv · Aug 16, 2021 · PreprintImmunology