Author

R. June

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Pathology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:metabolomics· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Approach:statistical model· 2

Frequent Co-Authors

B. Bothner· 3 shared A. K. Carlson· 2 shared D. L. Zignego· 2 shared H. Welhaven· 2 shared J. K. Hilmer· 2 shared A. E. Erdogan· 1 shared A. Welfley· 1 shared C. M. Heveran· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

B. Bothner

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Metabolomic Profiling and Characterization of a Novel 3D Culture System for Studying Chondrocyte Mechanotransduction

P. Brahmachary, A. E. Erdogan, E. Myers, R. June

This study develops a 3D culture system for chondrocytes that supports pericellular matrix development and enables mechanotransduction studies through metabolomic profiling.

bioRxiv · Jun 10, 2024Bioengineering

The metabolome of individuals with knee osteoarthritis is influenced by 18-months of an exercise and weight loss intervention and sex: the IDEA trial

H. Welhaven, A. Welfley, B. Bothner, S. Messier, R. Loeser, R. June

The paper examines how 18-months of diet, exercise, or combined interventions affect the serum metabolome of knee OA patients, revealing sex-specific metabolic changes.

bioRxiv · Feb 15, 2024 · PreprintBiochemistry

The gut microbiome has sexually dimorphic effects on bone tissue energy metabolism and multiscale bone quality in C57BL/6J mice

G. Vahidi, M. Moody, L. Davidson, H. Welhaven, S. Walk, S. Martin, R. June, C. M. Heveran

This study shows that the gut microbiome affects bone metabolism and quality differently in male and female mice, with sex-specific changes in metabolism, mineralization, and biomechanics.

bioRxiv · Nov 7, 2022 · PreprintMicrobiology

Primary human chondrocytes respond to compression with plasma membrane receptors and by microtubule activation: a phosphoproteomic study

D. L. Zignego, J. K. Hilmer, B. Bothner, W. J. Schell, R. June

This study identifies phosphoproteomic responses of osteoarthritic chondrocytes to compression, revealing microtubule and calcium signaling activation.

bioRxiv · Jun 15, 2019 · PreprintBioengineering

Characterization of osteoarthritis phenotypes by global metabolomic profiling of human synovial fluid

A. K. Carlson, R. A. Rawle, C. W. Wallace, E. G. Brooks, E. Adams, M. C. Greenwood, M. Olmer, M. Lotz, B. Bothner, R. June

This study identifies distinct metabolic phenotypes in human synovial fluid across osteoarthritis stages, revealing disease-specific metabolic pathways and potential biomarkers.

bioRxiv · Sep 7, 2018 · PreprintPathology

Inhibition of Early Response Genes Prevents Changes in Global Joint Metabolomic Profiles in Mouse Post-Traumatic Osteoarthritis

D. R. Haudenschild, A. K. Carlson, D. L. Zignego, J. H. N. Yik, J. K. Hilmer, R. June

This study inhibits early response genes in mice with joint injury to prevent metabolomic changes associated with post-traumatic osteoarthritis, identifying drug-responsive metabolites.

bioRxiv · Jul 29, 2018Pathology