Author

R. K. Castellano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

B. J. Davis· 2 shared B. K. Law· 2 shared C. D. Heldermon· 2 shared E. Yaaghubi· 2 shared M. E. Law· 2 shared A. F. Ghilardi· 1 shared A. Ghilardi· 1 shared C. M. Schilson· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

B. J. Davis

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 17, 2021

Repurposing Tranexamic Acid as an Anticancer Agent

M. E. Law, B. J. Davis, A. F. Ghilardi…·B. K. Law

This study shows Tranexamic Acid inhibits cancer growth by blocking Plasmin-mediated CDCP1 cleavage and disrupts multiple intracellular signaling pathways.

DOI 10.1101/2021.10.17.464714

humanmouse

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivJan 13, 2021

Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death

M. E. Law, E. Yaaghubi, A. Ghilardi…·B. K. Law

This study identifies DDAs as inhibitors of AGR2 and ERp44, showing they induce DR4/5 oligomerization and cancer cell death via disrupting disulfide bonds.

DOI 10.1016/j.canlet.2022.215604

humanproteomics

𝕏 PostBluesky