ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by promoting apoptosis resistance and metabolic dysregulation
P. Przanowski, R. K. Przanowska, M. J. Guertin
This study identifies ANKLE1 as a causal gene in the chr19p13.1 locus associated with cancer risk, showing it promotes apoptosis resistance and metabolic dysregulation through mitochondrial DNA cleavage.
bioRxiv · Oct 27, 2021Cancer Biology