Impaired alanine transport or exposure to D-cycloserine increases the susceptibility of MRSA to beta-lactam antibiotics
L. Gallagher, R. K. Shears, C. Fingleton, L. Alvarez, E. Waters, J. Clarke, L. Bricio-Moreno, C. Campbell, A. Yadav, F. Razvi, E. O'Neill, A. O'Neill, F. Cava, P. Fey, A. Kadioglu, J. P. O'Gara
The paper shows that impairing alanine transport or exposing MRSA to D-cycloserine increases susceptibility to beta-lactam antibiotics by reducing peptidoglycan crosslinking.
bioRxiv · Sep 19, 2019Microbiology