A. Yadav

Time course metabolomics and 13CO2 mapping establish BBX31/miP1b mediated metabolic readjustments conferring UV-B tolerance in Arabidopsis

This study identifies BBX31/miP1b-mediated metabolic changes in Arabidopsis under UV-B stress using metabolomics and 13CO2 tracing, showing increased phenylalanine and other protective metabolites.

Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19)

This paper identifies high-affinity inhibitors of B0AT1 and elucidates their mechanism of action through cryo-EM structures.

Identifying Selectivity Filters in Protein Biosensor for Ligand Screening

The paper identifies selectivity filters in MopR, a bacterial phenol biosensor, that screen ligands based on chemical features and size, revealing conserved mechanisms for ligand selection.

RNA- and ATAC-sequencing Reveals a Unique CD83+ Microglial Population Focally Depleted in Parkinson's Disease

The paper uses single-nucleus RNA- and ATAC-sequencing to identify a CD83+ microglial subpopulation depleted in Parkinson's disease, with implications for neuronal vulnerability.

Chimera alert! The threat of chimeric sequences causing inaccurate taxonomic classification of phytoplasma strains

This study identifies chimeric 16S rRNA gene sequences in phytoplasma strains using ChimeraSlayer and UCHIME, highlighting their threat to accurate taxonomic classification.

Comparative Transcriptomics and Genomics from Continuous Axenic Media Growth Identifies Coxiella burnetii Intracellular Survival Strategies

The paper identifies Coxiella burnetii survival strategies by comparing transcriptomic and genomic changes during axenic growth.

Characterizing the Interactions of Cell Membrane-Disrupting Peptides with Lipid-Functionalized Single-Walled Carbon Nanotube Systems for Antimicrobial Screening

This paper uses molecular dynamics simulations to study how three antimicrobial peptides interact with lipid-functionalized SWNTs, showing that they induce different structural perturbations in the lipid corona.

Zinc nano-fertilization enhances wheat productivity and biofortification

This study evaluates zinc oxide nanoparticles (ZnO-NPs) and zinc sulfate (ZnSO4) on wheat growth, yield, and grain zinc concentration, finding ZnO-NPs more effective for biofortification and yield enhancement.

A novel fluorobenzothiazole RBx 10080758 as a dual inhibitor against bacterial GyraseB (GyrB) and Topoisomerase IV (parE) of Gram-positive pathogens causing skin and respiratory infections

This paper evaluates a novel fluorobenzothiazole inhibitor, RBx 10080758, showing potent in vitro and in vivo activity against drug-resistant Gram-positive bacteria by dual targeting Gyrase B and Topoisomerase IV.

Targeting MALAT1 Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer.

This paper shows that inhibiting MALAT1 increases sensitivity to PARP inhibitors in prostate cancer by impairing homologous recombination.

Optimized transcriptional signature for evaluation of MEK/ERK pathway baseline activity and long-term modulations in ovarian cancer

The paper validates a multi-cancer transcriptional signature for MEK/ERK pathway activity in ovarian cancer using experimental models and TCGA data, showing gene expression associations with survival and treatment resistance.

Seeing the unseen: A trifoliate (MYB117) mutant allele fortifies folate and carotenoids in tomato fruits

A tomato trifoliate allele encoding a truncated MYB117 transcription factor alters cellular homeostasis and fortifies γ-aminobutyric acid, folate, and carotenoids in tomato fruits.

Effect of artificial light at night on sleep and metabolism in weaver birds

This study examines the effects of artificial light at night on sleep and metabolism in baya weavers, finding acute exposure causes more pronounced behavioral and physiological changes.

Genomic analysis of family UBA6911 (Group 18 Acidobacteria) expands the metabolic capacities of the phylum and highlights adaptations to terrestrial habitats

This study analyzes genomes from the Acidobacteria family UBA6911 to reveal their metabolic versatility and adaptations to different terrestrial and non-terrestrial habitats.

The males of the parasitoid wasp, Nasonia vitripennis, can identify which fly hosts contain females.

This study shows that male Nasonia vitripennis can detect female-specific cuticular hydrocarbons to identify fly hosts containing adult females, revealing a unique mate-finding strategy.

Elucidating biosynthetic pathway of piperine using comparative transcriptome analysis of leaves, root, and spike in Piper longum L.

The paper uses transcriptome analysis of P. longum leaves, roots, and spikes to identify gene families involved in piperine biosynthesis and validates gene expression with qRT-PCR.

Cuticular hydrocarbon divergence in Drosophila melanogaster populations evolving under differential operational sex ratios

This study examines cuticular hydrocarbon divergence in Drosophila melanogaster populations under differential sexual conflict and finds no significant differences between high and low conflict regimes.

Glycan processing in the Golgi - optimal information coding and constraints on cisternal number and enzyme specificity

The paper quantitatively analyzes tradeoffs between Golgi cisternal number and enzyme specificity to determine optimal conditions for synthesizing complex glycan distributions.

Rational design of protein-specific folding modifiers

This paper designs a method to create protein-specific folding modifiers using xenonuclei, showing they can accelerate protein refolding by 33% under specific conditions.

Impaired alanine transport or exposure to D-cycloserine increases the susceptibility of MRSA to beta-lactam antibiotics

The paper shows that impairing alanine transport or exposing MRSA to D-cycloserine increases susceptibility to beta-lactam antibiotics by reducing peptidoglycan crosslinking.

Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

This study shows that androgen deprivation therapy upregulates SPINK1, which enhances cellular plasticity and contributes to poor outcomes in prostate cancer.

Epigenetic silencing of miRNA-338-5p and miRNA-421 drives SPINK1-positive prostate cancer.

This study identifies miRNA-338-5p and miRNA-421 as epigenetically silenced in SPINK1-positive prostate cancer, and shows their restoration inhibits oncogenic properties.