Role of Rv3351c in trafficking Mycobacterium tuberculosis bacilli in alveolar epithelial cells and its contribution to disease
M. Prescott, K. Fine-Coulson, M. Metcalfe, T. Gupta, M. Dookwah, R. Pavlicek, H. Yahyaoui Azami, B. Reaves, A. Hikal, M. Tiemeyer, R. Karls, F. Quinn
This study identifies Rv3351c as a M. tuberculosis protein that facilitates bacilli trafficking through alveolar epithelial cells by inducing lipid raft aggregation and reducing phagolysosome fusion.
bioRxiv · Dec 3, 2020 · PreprintMicrobiology