Active Receptor Tyrosine Kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish
G. D'Agati, E. M. Cabello, K. Frontzek, E. J. Rushing, R. Klemm, M. Robinson, R. M. White, C. Mosimann, A. Burger
This study identifies that RTKs EGFR and KDR/VEGFR2, not Brachyury, can induce chordoma in zebrafish by disrupting notochord differentiation through RTK/Ras signaling.
bioRxiv · Nov 29, 2018Cancer Biology