Mapping the Structural and Dynamic Determinants of pH-sensitive Heparin Binding to Granulocyte Macrophage-colony Stimulating Factor
J. Y. Cui, F. Zhang, R. Linhardt, G. P. Lisi
This study investigates the pH and heparin chain length dependence of GMCSF-heparin binding using NMR, SPR, and molecular docking, revealing dynamic structural changes and a proposed binding mechanism.
bioRxiv · Mar 11, 2020Biochemistry