Author

J. Y. Cui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

H. Gu· 2 shared A. Beck· 1 shared A. Chandran· 1 shared A. Matson· 1 shared A. P. Naren· 1 shared A. Schon· 1 shared A. Vrzalova· 1 shared A. Zhang· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersPharmacology & Toxicology

H. Gu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Single cell transcriptomics unveiled that early life BDE-99 exposure reprogrammed the gut-liver axis to promote a pro-inflammatory metabolic signature in male mice at late adulthood

J. J. Lim, M. Goedkin, Y. Jin, H. Gu, J. Y. Cui

This study shows that neonatal BDE-99 exposure leads to persistent pro-inflammatory and metabolic dysregulation in the liver of male mice at late adulthood, linked to gut microbiome changes.

bioRxiv · Jun 22, 2023Pharmacology & Toxicology

Mapping the Structural and Dynamic Determinants of pH-sensitive Heparin Binding to Granulocyte Macrophage-colony Stimulating Factor

J. Y. Cui, F. Zhang, R. Linhardt, G. P. Lisi

This study investigates the pH and heparin chain length dependence of GMCSF-heparin binding using NMR, SPR, and molecular docking, revealing dynamic structural changes and a proposed binding mechanism.

bioRxiv · Mar 11, 2020Biochemistry

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

Z. Dvorak, F. Felix Kopp, C. M. Costello, J. S. Kemp, H. Li, A. Vrzalova, M. Stepankova, I. Iveta Bartonkov, K. Poulikova, B. Vyhlidalova, L. U. Nordstroem, C. Karunaratne, H. Ranhotra, K. S. Mun, A. P. Naren, , R. B. Sartor

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.

bioRxiv · Jan 3, 2020Biochemistry

Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism

A. Zhang, J. Y. Cui, C. Y. Li, E. J. Kelly, L. Sheppard

This study identifies lncRNA-PCG pairs regulated by PBDE exposure and their involvement in intermediary metabolism pathways.

bioRxiv · Oct 21, 2019Pharmacology & Toxicology