Differential chondrogenic differentiation between iPSC-derived from healthy and OA cartilage is associated with changes in epigenetic and metabolic transcriptomic signatures
M. N. Khan, M. E. Diaz-Hernandez, S. Chihab, P. Priyadarshani, P. Bhattaram, L. J. Mortensen, R. M. Guzzo, H. Drissi
The paper compares chondrogenic differentiation potential of iPSCs derived from healthy and OA cartilage, finding epigenetic and metabolic differences that affect their differentiation capacity.
bioRxiv · Oct 14, 2022Cell Biology