Author

L. J. Mortensen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:metabolomics· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

P. Priyadarshani· 3 shared B. Leitmann· 2 shared E. Botchwey· 2 shared K. F. Tehrani· 2 shared A. A. Nikitina· 1 shared A. Day· 1 shared A. E. Qualls· 1 shared A. R. Liversage· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCell Biology

P. Priyadarshani

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Differential chondrogenic differentiation between iPSC-derived from healthy and OA cartilage is associated with changes in epigenetic and metabolic transcriptomic signatures

M. N. Khan, M. E. Diaz-Hernandez, S. Chihab, P. Priyadarshani, P. Bhattaram, L. J. Mortensen, R. M. Guzzo, H. Drissi

The paper compares chondrogenic differentiation potential of iPSCs derived from healthy and OA cartilage, finding epigenetic and metabolic differences that affect their differentiation capacity.

bioRxiv · Oct 14, 2022Cell Biology

Integration of imaging modalities with lipidomic characterization to investigate MSCs potency metrics

L. J. Mortensen, P. Priyadarshani, A. R. Van Grouw, A. R. Liversage, A. A. Nikitina, K. F. Tehrani, M. L. Kemp, F. Fernandez

The paper investigates MSCs potency by integrating imaging and lipidomic data to correlate lipid signaling with phenotypic changes and subpopulation heterogeneity.

bioRxiv · May 25, 2022 · PreprintCell Biology

UNDESRTANDING MESENCHYMAL STEM CELL IMMUNE POTENCY:A MORPHOLOMIC AND LIPIDOMIC PERSPECTIVE

P. PRIYADARSHANI, S. DeVeaux, B. Leitmann, K. Rui, E. Botchwey, L. J. Mortensen

This study investigates MSC immune potency through morphologic and lipidomic analysis, showing sphingolipid pathway modulation enhances immunomodulatory activity.

bioRxiv · May 25, 2022 · PreprintCell Biology

Characterizing Human Mesenchymal Stromal Cells Immune Modulatory Potency Using Targeted Lipidomic Profiling of Sphingolipids

S. A. DeVeaux, M. E. Ogle, S. Vyshnya, N. F. Chiappa, B. Leitmann, R. Rudy, A. Day, L. J. Mortensen, J. Kurtzberg, K. Roy, E. Botchwey

This study uses lipidomic profiling to characterize sphingolipids in MSCs from different sources and identifies sex- and stimulation-dependent differences in ceramide levels linked to immune modulatory potency.

bioRxiv · Jun 1, 2021Bioengineering

PGC-1α overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury

W. M. Southern, A. S. Nichenko, K. F. Tehrani, M. J. McGranahan, L. Krishnan, A. E. Qualls, N. J. Jenkins, L. J. Mortensen, H. Yin, A. Yin, R. E. Guldberg, S. M. Greising, J. A. Call

This study shows that PGC-1α overexpression improves oxidative capacity and muscle strength in VML-injured muscle, suggesting it as a potential therapeutic target.

bioRxiv · Jan 31, 2019Physiology