Author

R. M. Ryan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1

Frequent Co-Authors

E. Tajkhorshid· 2 shared Q. Wu· 2 shared S. Pant· 2 shared A. G. Stewart· 1 shared I. Chen· 1 shared J. Font· 1 shared M. Sobti· 1 shared R. Cater· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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2 shared papersBiophysics

E. Tajkhorshid

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2 papers

Recent·Most cited

Microscopic Characterization of the Chloride Permeation Pathway in the Human Excitatory Amino Acid Transporter 1 (EAAT1)

S. Pant, Q. Wu, R. M. Ryan, E. Tajkhorshid

This study identifies a chloride-conducting conformation in human EAAT1 using MD simulations and mutagenesis, revealing a conserved mechanism across SLC1A family transporters.

bioRxiv · Nov 20, 2021Biophysics

Glutamate transporters contain a conserved chloride channel with two hydrophobic gates

I. Chen, S. Pant, Q. Wu, R. Cater, M. Sobti, R. Vandenberg, A. G. Stewart, E. Tajkhorshid, J. Font, R. M. Ryan

The paper reports the cryo-EM structure of a glutamate transporter homologue, revealing a conserved chloride channel with two hydrophobic gates that facilitates dual-function transport.

Nature · Feb 17, 2021Peer-reviewedBiophysics