M. Sobti

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

This paper isolates broadly neutralizing SARS-CoV-2 antibodies from convalescent patients and shows they neutralize emerging variants more effectively than existing monoclonal antibodies.

Molecular basis for GIGYF-TNRC6 complex assembly in miRNA-mediated translational repression

This study determines the crystal structures of GIGYF1/2 GYF domains interacting with TNRC6 proteins, revealing how they bridge 4EHP to miRNA targets for translational repression.

Glutamate transporters contain a conserved chloride channel with two hydrophobic gates

The paper reports the cryo-EM structure of a glutamate transporter homologue, revealing a conserved chloride channel with two hydrophobic gates that facilitates dual-function transport.

The six steps of the F1-ATPase rotary catalytic cycle

This study determines the structure of the binding dwell state of F1-ATPase and provides a structural basis for the entire rotary catalysis cycle.

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

This paper explores antibody maturation strategies to enhance the neutralization of SARS-CoV-2 using SARS-CoV-1 antibodies, finding that some variants show potent neutralization with IC50 of 160 ng/ml.

Subunit epsilon of E. coli F1Fo ATP synthase attenuates enzyme activity by modulating central stalk flexibility

This study presents cryo-EM structures of E. coli ATP synthase showing how the ε subunit modulates central stalk flexibility to regulate enzyme activity.

Structural analysis of Sulfolobus solfataricus TF55β chaperonin in open and filamentous states

The paper reports the structures of TF55β chaperonin from Sulfolobus solfataricus in open and filamentous states using cryo-EM, revealing conformational changes related to nucleotide binding and filament formation.

Visualizing movements in E. coli F1Fo ATP synthase indicates how the F1 and Fo motors are coupled

The paper presents high-resolution cryo-EM structures of E. coli F1Fo ATP synthase and describes a rotational sub-step of the Fo motor that explains how the F1 and Fo motors are coupled with minimal energy loss.