Author

R. M. Saecker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Assay:structural biology· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

B. Malone· 2 shared E. T. Eng· 2 shared J. Chen· 2 shared L. Y. Yen· 2 shared S. A. Darst· 2 shared A. U. Mueller· 1 shared B. Carragher· 1 shared C. E. Chiu· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiophysics

B. Malone

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Author profile →

2 papers

Recent·Most cited

Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy

R. M. Saecker, A. U. Mueller, B. Malone, J. Chen, W. C. Budell, V. P. Dandey, K. Maruthi, J. H. Mendez, N. Molina, E. T. Eng, L. Y. Yen, C. S. Potter, B. Carragher, S. A. Darst

This study uses time-resolved cryo-EM to visualize early intermediates in bacterial RNA polymerase promoter melting, revealing key steps in the formation of the transcription-competent open complex.

bioRxiv · Mar 13, 2024Biophysics

Structural origins of Escherichia coli RNA polymerase open promoter complex stability

R. M. Saecker, J. Chen, C. E. Chiu, B. Malone, J. Sortiris, M. Ebrahim, L. Y. Yen, E. T. Eng, S. A. Darst

This study determines the structural basis of RNA polymerase open complex stability in E. coli by analyzing three promoters with different lifetimes using cryo-EM.

bioRxiv · Sep 8, 2021Biophysics