Adaptation of redox metabolism in drug-tolerant persister cells is a vulnerability to prevent relapse in pancreatic cancer
N. Abdel Hadi, G. Reyes-Castellanos, T. Gicquel, S. Gallardo-Arriaga, E. Boet, J.-E. Sarry, R. Masoud, J. L. IOVANNA, A. Carrier
This study identifies mitochondrial and redox metabolic reprogramming in drug-tolerant persister cells of pancreatic cancer and shows that targeting redox metabolism can prevent relapse.
bioRxiv · Dec 28, 2022 · PreprintCancer Biology