The linkage of methionine addiction, overmethylation of histone H3 lysines and malignancy demonstrated when cancer cells revert to methionine-independence
J. Yamamoto, S. Inubushi, Q. Han, Y. Tashiro, N. Sugisawa, K. Hamada, Y. Aoki, K. Miyake, R. Matsuyama, M. Bouvet, S. G. Clarke, I. Endo, R. M. Hoffman
The paper shows that methionine-independent cancer cell revertants have reduced histone H3 lysine trimethylation and lower tumorigenicity and metastatic potential compared to methionine-addicted parental cells.
bioRxiv · Dec 4, 2020 · PreprintCancer Biology