Author

R. M. Hoffman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. Yamamoto· 3 shared K. Hamada· 3 shared M. Bouvet· 3 shared Y. Aoki· 3 shared I. Endo· 2 shared N. Sugisawa· 2 shared S. Inubushi· 2 shared Y. Tashiro· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

J. Yamamoto

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Author profile →

3 papers

Recent·Most cited

A triple-negative matrix-producing breast carcinoma is arrested by tumor-targeting Salmonella typhimurium A1-R in a PDOX model

K. Hamada, J. Yamamoto, C. Hozumi, M. Zhao, T. Murata, N. Sugisawa, Y. Sun, Y. Aoki, H. Nishino, M. Bouvet, T. Tsunoda, R. M. Hoffman

This study evaluates the efficacy of Salmonella typhimurium A1-R in arresting tumor growth in a triple-negative matrix-producing breast carcinoma PDOX model.

bioRxiv · Jan 14, 2021 · PreprintCancer Biology

Histone H3K4me3 and H3K9me3 are super over-methylated in soft tissue sarcoma compared to normal muscle in patient-derived xenograft (PDX) mouse models: an indicator of cancer methionine addiction

Y. Aoki, R. M. Hoffman, K. Nishida, I. Endo, M. Bouvet, Y. Tashiro, S. Inubushi, K. Hamada, Y. Tome, J. Yamamoto

bioRxiv · Jan 1, 2021 · PreprintCancer Biology

The linkage of methionine addiction, overmethylation of histone H3 lysines and malignancy demonstrated when cancer cells revert to methionine-independence

J. Yamamoto, S. Inubushi, Q. Han, Y. Tashiro, N. Sugisawa, K. Hamada, Y. Aoki, K. Miyake, R. Matsuyama, M. Bouvet, S. G. Clarke, I. Endo, R. M. Hoffman

The paper shows that methionine-independent cancer cell revertants have reduced histone H3 lysine trimethylation and lower tumorigenicity and metastatic potential compared to methionine-addicted parental cells.

bioRxiv · Dec 4, 2020 · PreprintCancer Biology