Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis
D. Guillotin, A. Taylor, M. Plate, P. Mercer, L. Edwards, R. Haggart, G. Miele, R. McAnulty, T. Maher, R. E. Hynds, M. Jamal-Hanjani, R. Marshall, A. Fisher, A. Blanchard, R. Chambers
This study identifies key transcriptional pathways in IPF fibroblastic foci using RNA-seq and bioinformatics, highlighting the TSC2/RHEB axis as a potential therapeutic target for fibrosis.
bioRxiv · Mar 10, 2020Cell Biology