A. Blanchard

Can a bulky glycocalyx promote catch bonding in early integrin adhesion? Perhaps a bit

This paper investigates whether a bulky glycocalyx promotes catch bonding in integrin adhesion, finding it can increase bond lifetime and adhesion formation rates.

GDF15 mediates renal cell plasticity in response to potassium depletion

This study shows that GDF15 mediates renal cell plasticity in response to potassium depletion by regulating intercalated cell numbers and K+ retention.

Unblocking genome editing of major animal mycoplasmas using CRISPR/Cas9 base editor systems

This paper develops a CRISPR/Cas9 base editor system to efficiently edit the genomes of three major mycoplasma pathogens, enabling the study of virulence factors and vaccine development.

Tuning spherical cells into kinking helices in wall-less bacteria

This study expresses Spiroplasma MreB isoforms and fibrils in Mycoplasma to induce helical shapes and kink-like motility, revealing MreB5's role in helicity and suggesting additional factors are needed for swimming.

Garlic-derived organosulfur compounds regulate metabolic and immune pathways in macrophages and attenuate intestinal inflammation in mice

This study shows garlic-derived organosulfur compounds reduce inflammation in macrophages and intestinal epithelial cells, and alter gene expression during intestinal infection in mice.

The phytonutrient cinnamaldehyde limits intestinal inflammation and enteric parasite infection

This study shows that cinnamaldehyde reduces intestinal inflammation and improves resistance to enteric parasite infection in mice, independent of gut microbiota.

Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis

This study identifies key transcriptional pathways in IPF fibroblastic foci using RNA-seq and bioinformatics, highlighting the TSC2/RHEB axis as a potential therapeutic target for fibrosis.

Strongyle-resistant sheep express their potential across environments and leave limited scope for parasite plasticity

The paper breeds sheep resistant to parasites and finds that resistance remains stable across environments but is affected by specific parasite infections.

Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain

This paper attenuates a highly virulent Mycoplasma strain by deleting non-essential genes and demonstrates its safety in vivo using a goat model.

Risk factor analysis of equine strongyle resistance to anthelmintics

This study identifies risk factors for anthelmintic resistance in equine strongyles using data from 688 horses, showing that FEC-based treatment and biosecurity measures reduce resistance risk.