Author

R. N. Philippe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biochemistry· 1

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:plant (other)· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Pabis· 1 shared A. T. Nelson· 1 shared D. S. Tawfik· 1 shared G. A. Cortina· 1 shared G. V. Louie· 1 shared J. J. LaClair· 1 shared J. M. Jez· 1 shared J. P. Noel· 1 shared

Activity by Year

2018-2018 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. Pabis

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1 paper

Recent·Most cited

Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases

J. R. Burke, J. J. LaClair, R. N. Philippe, A. Pabis, J. M. Jez, G. A. Cortina, M. Kaltenbach, M. E. Bowman, G. V. Louie, K. B. Woods, A. T. Nelson, D. S. Tawfik, S. C. L. Kamerlin, J. P. Noel

The paper elucidates the catalytic mechanism of chalcone isomerases, showing how an arginine residue activates substrates via Bronsted and Lewis acid interactions, and highlights structural differences between type-1 and type-2 enzymes.

bioRxiv · Oct 30, 2018Biochemistry